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The microarray study suggests that RpoN positively regulates the expression of genes essential for acetate oxidation coupled to metal reduction such as fumarase (GSU0994) and acetyl-CoA transferases (GSU0174 and GSU0490) [ 45].
The fact that we were able to confirm the differential expression of DSC1 and DSG1 by q-PCR in 2 week old samples as opposed to week 1 biopsies used in the microarray study suggests that the lowered expression of these adhesion molecules maybe be prolonged for the duration of horn development.
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In addition, a recent cDNA microarray study suggested that upregulation of several genes of translation apparatus is generally involved in metastasis of cancer (Ramaswamy et al, 2003).
The microarray study suggested that levels of PPP1R1A were increased nearly 2-fold in Ad5 E1-transformed cells over untransformed BRK cells, which was confirmed by the real-time PCR data.
Evidence from microarray studies suggests that single miRNAs can target hundreds of messenger RNAs [19] and recent in vivo studies of loss-of-function phenotypes demonstrate the important regulatory role of miRNAs e.g. in development [20] [23], homeostasis [24] or disease [25].
The lack of genes consistently regulated by high Se in these microarray studies suggests that the genes so far identified may not be useful as Se-specific molecular biomarkers.
Microarray studies suggest that epigenetic factors can have extensive effects on levels of gene expression [7].
Interestingly, microarray studies suggested that distinct subsets of direct RA target genes differentially responded to RIP140 depletion [12].
However, recent microarray studies suggested that the pleiotropic antiproliferative and apoptotic effects of the broad-spectrum HDACIs may be more beneficial than an isoform-specific drug [16], [45].
Third, 13 of the 50 genes listed in Table 1 have also been identified as NGF-responsive in previous microarray studies, suggesting that the identified genes are highly likely to be involved in the differentiation process of PC12 cells, especially during the action of the first stimulation (Table 1) [29]–[31].
Results from both microarray studies suggest that citrinin treatment induced oxidative stress in yeast cells.
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