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In murine cells, a recent study of gene expression of a significant proportion of TRIM proteins and an additional microarray study provided some insight into the expression of this protein family in mouse [34], [35].
Indeed, the microarray study provided a wealth of information that allowed for hypothesis generation to earmark the switch from dysplasia to malignant transformation and the discovery of molecular events in lung cancer induced by exaggerated c-Raf activity (Figure 14).
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The EST data obtained and submitted to the GenBank database as well as the transcriptional profiling from the microarray study provide sequence and differential gene expression information for hepatic genes in the pig.
These microarray studies provided a first characterization of temporal and spatial gene expression patterns in many different organisms, but they also had obvious limitations since they were dependent on already available sequence information from the organism of interest.
The data obtained from the microarray studies provide further insight in gene expression during bovine embryonic development.
Microarray studies provide insight into cartilage aging but do not reveal the full transcriptomic phenotype of chondrocytes such as small noncoding RNAs, pseudogenes, and microRNAs.
Microarray studies provide simultaneously measurement of thousands of genes, having therefore been used to identify many differentially expressed genes and expression profiles in HNSCC.
Recent microarray studies provide further evidence for large changes in the pattern of gene expression across species and suggest that such changes have played roles in evolution (Enard, Khaitovich, et al. 2002; Cáceres et al. 2003; Preuss et al. 2004; Uddin et al. 2004).
In summary, our microarray expression study provides a detailed overview of differentially expressed genes, networks, and pathways between BRAFwt and BRAFmut PTCs that gain interest for basic molecular genetics and translational studies in PTCs.
The DNA microarray analysis in the present study provided new information for the involvement of numerous interleukin family members in brain ischemia.
It is important to note that the long oligonucleotide probes (60 80 mer) on the NimbleGen microarrays we used in this study provided excellent detection sensitivity and reliability (see Table 1, Figures 5A C and Figure 6).
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