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Many downstream targets of TNF are also stimulated by type I IFN, as was demonstrated in a recent microarray study comparing cellular responses to treatment with each cytokine [35].
In search for novel and potentially relevant targets for androgen action we screened the data from an earlier microarray study comparing transcript levels in SCARKO and control animals between day 8 and 20 [19] for genes displaying striking differential expression patterns.
This is consistent with results from a microarray study comparing male and female bovine embryos where differentially expressed genes were enriched to the sex chromosomes [ 38].
Therefore, we performed a microarray study comparing gene expression profiles of circulating and marrow-derived T-cells at initial presentation and after hematological recovery in order to elucidate more details of the mechanism resulting in severe bone marrow failure.
Three components of the mitochondrial electron transport chain (UQCRB and COX6C, COX7B) were also more highly expressed in lymphocytes than granulocytes, a finding that is also consistent with a previous microarray study comparing whole blood and PBMC [ 11].
In fact, IL-8 was shown to be upregulated in smokers with lung cancer in a microarray study comparing gene expression in normal large-airway epithelial cells between smokers with or without lung cancer (Spira et al, 2007).
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In esophageal adenocarcinoma, the amplification of Bmi-1 was very low (3%) by DNA microarray study compared with to the high expression (37%) by immunohistochemical study.
However, the level of regulation of some of these transcripts, such as akt2, bik, birc2 (IAP-1) and birc3 (IAP-2) was deeply underestimated by the microarray study (compare Figure 4b and Supplementary Table S1).
More recently, a microarray study compared genome-wide expression in embryonic mouse ovaries, the aim being to identify novel genes associated with early female meiosis, and reported that around 200 genes were differentially expressed in E13.5 mouse ovaries compared with E11.5 ovaries [ 28].
Much of this difference may be explained by the fact that the microarray study compared 43 strains representing types B, E and F whereas the reciprocal best match analysis compared only three genomes including a single type B strain and no type F strain.
Microarray studies comparing gene expression profiles of macrophages and progenitor/stem cells indicate that both cell types demonstrate the capacity for endocytosis, vesicle trafficking, and actin remodeling [40].
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