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Recent microarray studies support this hypothesis by showing that the decline in gene expression within the aging human brain is associated with a corresponding increase in DNA lesions (i.e., 8-oxodexoyguanosine) within the promoter region of key genes involved in learning, memory, and neuronal survival (i.e., synaptic plasticity) (Lu et al. 2004).
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Our microarray study supported this observation [ 59].
Our DNA microarray studies lends support to a previous report that p16 and p53 play important roles in early carcinogenesis of esophageal adenocarcinoma [ 36].
The microarray study was supported by NIH grant NS28869 (to ES).
Metabolic and microarray studies in AS11 alone support this hypothesis as LPCAT2 expression and LPCAT activity are up-regulated in the absence of DGAT1.
These data support earlier microarray studies on root buds of leafy spurge which indicated that flavanoid biosynthetic genes were down-regulated following release from paradormancy [ 56].
The circadian rhythmicity of many cartilage specific genes found in mouse is supported by microarray studies in rat cartilage under diurnal (LD cycle) conditions [ 72].
It should be acknowledged that very small microarray studies may have too few samples to support permutation.
The provisional annotation of genes is supported by expression data from microarray studies described in companion papers.
The deduction that these small chloroplast-targeted DnaJ proteins are related to regulation of CO2 assimilation is also supported by the data from DNA microarray studies.
Many new bioinformatics approaches are being developed to support the analysis of the large amount of data generated by microarray studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com