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Third, 13 of the 50 genes listed in Table 1 have also been identified as NGF-responsive in previous microarray studies, suggesting that the identified genes are highly likely to be involved in the differentiation process of PC12 cells, especially during the action of the first stimulation (Table 1) [29]–[31].
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Microarray studies suggest that epigenetic factors can have extensive effects on levels of gene expression [7].
Interestingly, microarray studies suggested that distinct subsets of direct RA target genes differentially responded to RIP140 depletion [12].
However, recent microarray studies suggested that the pleiotropic antiproliferative and apoptotic effects of the broad-spectrum HDACIs may be more beneficial than an isoform-specific drug [16], [45].
Evidence from microarray studies suggests that single miRNAs can target hundreds of messenger RNAs [19] and recent in vivo studies of loss-of-function phenotypes demonstrate the important regulatory role of miRNAs e.g. in development [20] [23], homeostasis [24] or disease [25].
Results from both microarray studies suggest that citrinin treatment induced oxidative stress in yeast cells.
On the other hand, protein microarray studies suggest that some TFs select novel binding motifs containing methylated CpG dinucleotides [ 56].
In particular, microarray studies suggest that domestication may also be associated with changes in gene expression [ 22, 35- 37].
Microarray studies suggest that hrpL represents only one branch of the regulatory pathways downstream of hrpRS, and a large number of genes regulated by HrpRS are hrpL-independent in P. syringae [ 64].
DNA microarray studies suggested that proportion of silent OR genes that are not expressed in the olfactory epithelium is less than 30% in human and mouse (Zhang et al. 2004, 2007).
The lack of genes consistently regulated by high Se in these microarray studies suggests that the genes so far identified may not be useful as Se-specific molecular biomarkers.
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