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Interestingly, microarray studies suggested that distinct subsets of direct RA target genes differentially responded to RIP140 depletion [12].
However, recent microarray studies suggested that the pleiotropic antiproliferative and apoptotic effects of the broad-spectrum HDACIs may be more beneficial than an isoform-specific drug [16], [45].
DNA microarray studies suggested that proportion of silent OR genes that are not expressed in the olfactory epithelium is less than 30% in human and mouse (Zhang et al. 2004, 2007).
Results of our microarray studies suggested that a large fraction of transcribed Tc1-genes can be stimulated under acute conditions, but it remains unclear whether or not the transposon transcripts have any functional importance.
In this report, we studied the toxicity of citrinin to yeast cells using the traditional ORF (Open Reading Frame) DNA microarray [ 6] and Oligo (Oligo-nucleotide) DNA microarray systems [ 9]. Results from both microarray studies suggested that the oxidative stress was the main cause for toxicity, but this oxidative stress did not lead to any DNA damage.
Deep annotation of the intestinal mRNA sequence space is still missing, although microarray studies suggested a high complexity of region-specific expression patterns [ 22, 23] and disturbances of intestinal homeostasis are linked to a broad variety of diseases (e.g. infections, idiopathic inflammatory bowel disease and intestinal malignancies) [ 24, 25].
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Microarray studies suggest that epigenetic factors can have extensive effects on levels of gene expression [7].
Evidence from microarray studies suggests that single miRNAs can target hundreds of messenger RNAs [19] and recent in vivo studies of loss-of-function phenotypes demonstrate the important regulatory role of miRNAs e.g. in development [20] [23], homeostasis [24] or disease [25].
Third, 13 of the 50 genes listed in Table 1 have also been identified as NGF-responsive in previous microarray studies, suggesting that the identified genes are highly likely to be involved in the differentiation process of PC12 cells, especially during the action of the first stimulation (Table 1) [29]–[31].
Results from both microarray studies suggest that citrinin treatment induced oxidative stress in yeast cells.
On the other hand, protein microarray studies suggest that some TFs select novel binding motifs containing methylated CpG dinucleotides [ 56].
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