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This finding corroborates previous microarray studies showing that, in general, more genes are upregulated than downregulated in aging liver [ 5].
Genetic biomarkers can include biomarkers of susceptibility, as shown in Table 1, as well as indicate subclinical precursors to adverse effects as provided in genomic RNA microarray studies showing changes in gene expression profiles.
However, there are technical challenges considering the more than 500 PicTar predicted mRNA targets, and microarray studies showing less than 2 fold changes in miRNA expression is most common.
Those observations have been supported in recent years by microarray studies showing elevated expression of a broad spectrum of IFN-inducible genes in peripheral blood cells of many lupus patients (the 'IFN signature').
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The results of the microarray studies show that the in vitro profiles of gene expression cluster per compound and incubation time, and when analyzed in a commercial gene expression database, can predict the toxicity and pathology observed in vivo.
Microarray studies showed that gene expression spanning a region of approximately 84 kb upstream of the mutated gene was downregulated.
Microarray studies showed that subsets of genes induced by IFN-γ were inhibited by exosomes from H37Rv-infeced cells including genes involved in antigen presentation.
Bioinformatics analyses based on EST sequences and exon-exon junction microarray studies show that 59% ∼74%of human genes are alternatively spliced [1], [2].
Indeed, recent microarray studies showed Nur77 induces known apoptotic genes such as FasL and TRAIL, but also novel genes such as NDG1 and NDG2 that promote apoptosis in a Bcl-2-independent manner [17].
In line with the pathogen dependent induction of AtWAKL10 and the ECGG50, microarray studies showed that the expression of the genes was induced by the functional synthetic SA analogue, benzothiadiazole S-methylester (BTH) (+1.59, 8 and 24 hat) in an NPR1-dependent manner (Figure 9A).
Microarray studies show that from 5-105-10%trarecripts arexpresseded with 24-hour rhythmicity.
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