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Numerous microarray studies reported different expression patterns of miRNAs in breast cancers and found clinical interest for several miRNAs but often with contradictory results.
The statistical analysis of microarrays (SAM) method [ 22] was used to determine significance in all microarray studies reported in this communication.
For example, microarray studies reported synchronous upregulation of several GST enzymes in flies [ 29], and it is known that glutathione participates in the conjugation of oxidized proteins [ 30].
Microarray studies reported that caspofungin induces expression of several genes encoding cell wall proteins and cell wall maintenance proteins both in S. cerevisiae and C. albicans (Bruno et al., 2006; Lesage et al., 2004; Liu et al., 2005; Reinoso-Martin et al., 2003).
In addition, the application of more extensive analysis with global methods, such as DNA microarray studies reported for B. subtilis [ 60] and S. pneumoniae [ 61], might allow defining the regulons and the potential regulatory functions of TCS proteins in response to environmental signals.
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Up to now, all microarray studies reporting gene expression changes in response to morphine have been conducted in rodents and humans.
While many microarray studies report that similar classifications are obtained with different supervised learning algorithms [ 13, 14, 28, 29], so far little attention has been paid to this critical aspect of selecting discriminating genes [ 30- 32].
Although prolonged application of fluid shear increased the mRNA synthesis of TCDD-inducible poly(ADP-ribose) polymerase (PARP-1) in human T/C-28a2 chondrocytes (Table 1), a recent microarray study reported this gene to be down-regulated in OA chondrocytes relative to normal controls [15].
A microarray study reported that SST gene expression is increased in the PFC of bipolar disorder but not with schizophrenia patients [ 59].
Consistent with our findings, a recent oligonucleotide microarray study reported that SPP1 was the most highly expressed gene in intrahepatic cholangiocarcinoma [ 45].
This sample was equivalent to the cabinet cauline leaf cDNA used as a control in comparisons with field samples for the microarray study reported by Guevara et al. [ 7].
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