Sentence examples for microarray studies observed from inspiring English sources
Although neglected and not primarily addressing PONs, some (microarray) studies observed marked overexpression of PON2 in cancers, for example, in hepatocellular carcinoma, prostate carcinoma or lymphocytes infected with T-cell leukemia virus PON2 was also highly upregulated in gene expression profiling studies addressing pediatric acute lymphoblastic leukemia (ALL).
Microarray studies have observed a high percent of expressed genes related to RNA post-transcriptional processing and protein processing in K. brevis, thus suggesting that this dinoflagellate species is highly reliant on post-transcriptional regulation [ 26].
Using these cell lines, we performed a pilot microarray study and observed significant decrease (around 7-fold) of the Beclin 1 transcript expression upon depletion of 14-3-3τ 14-3-3τ 14-3-3τ
Up-or down-regulation opposite to the direction of regulation obtained by the microarray study was observed by RT-qPCR for the five remaining genes, out of the total of 40.
In contrast to previous microarray studies in kinetoplastids, we observed that relative transcript abundances for over 50% of the genes detected on the T. cruzi microarrays were significantly regulated during the T. cruzi life-cycle.
The lack of a control group additionally makes the changes in gene expression observed in the microarray studies inconclusive with respect to whether they represent a change due to treatment or a change based on the natural history of the disease.
This inverse regulation argues for a specific effect mediated by the Aβ42/Aβ40 ratio itself, because an inverse Aβ42/Aβ40 ratio led to an inverse regulation of this gene and may not be mediated by unspecific effects occasionally observed in microarray studies.
Real-time qPCR results showed similar trends in gene expression changes as were observed in microarray studies.
These × and Y-linked genes are routinely observed in microarray studies of sex differences in hearts from humans and mice [ 23].
Here, a model of ovarian steroidogenesis in the fathead minnow, Pimephales promelas, (FHM) is developed to evaluate possible transcriptional regulation of steroid production observed in microarray studies.
The levels of selected mRNA and miRNA observed on microarray studies were validated by using a SYBR-based quantitative RT-PCR method [ 25].
