Nevertheless, microarray studies have generated new and interesting insights.
Several microarray studies have explored the DA transcriptome in animal models but varied experimental designs have led to conflicting results.
For example, microarray studies have revealed that genes involved in adherence are downregulated in Pseudomonas aeruginosa upon exposure to nitric oxide donors (Firoved et al. 2004).
Microarray studies have identified several genes involved in the GA pathway (Yazaki et al.[2003]; Yang et al.[2004]; Jan and Komatsu [2006]).
Similar microarray studies have also highlighted sex-specific microRNA expression profiles that are engaged in mice during early lung development and which may explain the impact of sex on aspects of normal and aberrant lung development [13].
In addition, microarray studies have been subject to several criticisms and concerns.
Genome tiling microarray studies have consistently documented rich transcriptional activity beyond the annotated genes.
Several microarray studies have examined circadian rhythms in global gene expression in Drosophila heads and bodies.
Other rice microarray studies have also revealed involvement of biochemical pathways in various processes.
Microarray studies have demonstrated changes in myelin transcripts in the nucleus accumbens and prefrontal cortex of cocaine abusers [14], [16].
In the past, microarray studies have been criticized due to noise and the limited overlap between gene signatures.
