In two independent patient cohorts, gene microarray studies demonstrated that Rab25 expression was decreased in colon cancers independent of clinical and pathological staging.
Likewise, patterns of altered gene expression, as detected by DNA microarray studies, demonstrated very different patterns at low versus higher doses (Andrew et al. 2003b).
Microarray studies demonstrated that overall miRNA expression could clearly separate normal versus cancerous breast tissue, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, mir-155, and mir 335.
Previous microarray studies demonstrated that the ParS/ParR TCST system controls the expression of the lipopolysaccharide modifying (arnBCADTEF-ugd), efflux (mexXY), porin (oprD), chitinase (chiC) and phenazine biosynthetic genes (phzA2B2) when exposed to subinhibitory concentrations of antimicrobial reagents [ 8, 9].
However, recently published microarray studies demonstrated the upregulation of DLX5 in several human solid tumors, suggesting that overexpression of DLX5 could contribute to tumor progression and represent a novel prognostic marker [ 12, 13].
Microarray studies demonstrated that VDR reactivation induced by the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) plus calcitriol uniquely upregulated a group of "repressed" gene targets associated with the control of proliferation and induction of apoptosis (Khanim et al. 2004; Rashid et al. 2001).
These findings are consistent with data from microarray studies demonstrating considerable diversity in dose response relationships of different estrogen-responsive genes; in particular, as one moves across the dose response curve, entirely different sets of genes are activated or inhibited (Coser et al. 2003; Shioda et al. 2006).
Identification of a Fur box is consistent with our previous microarray studies demonstrating increased so2426 mRNA levels in a S. oneidensis MR-1 fur knockout strain [ 31] and suggests that expression of the SO2426 response regulator might be subject to Fur-mediated repression.
As microarray studies demonstrated that these cases with atypical morphology shared a gene expression profile with BL 36, 37, cases defined as atypical BL according to the third edition of the WHO classification were then categorized as BL according to the fourth edition, suggesting that the morphological spectrum of BL is very wide 24, 35.
