A microarray study defined the expression properties of A. baumannii during growth in human serum and demonstrated significant over-expression of iron acquisition systems, of genes associated with epithelial cell adherence, DNA uptake and of numerous putative drug efflux pumps [ 39].
Furthermore, microarray expression profiling studies defined a gene expression signature of MYC-induced prostate cancer in Hi-MYC mice that shares a number of features with human prostate cancer [1], [45].
Most of the cDNA clones with signals above twice that of background were below the usual 2-fold threshold used by microarray studies to define genes that are dysregulated.
Extensive studies defining the global expression profiles upon the activation of wounding signaling pathways have been conducted using microarrays [ 19] and proteomic [ 20].
Furthermore, the identification of 28 protein-coding genes, detected in this and three previous microarray studies as differentially expressed, defined a core set of proteins involved in the iron-stress response.
Data collected from the aforementioned clinical trial were used to perform microarray studies in which to define a gene set in which to focus MT PCR studies.
While tumor subtypes still segregate primarily by expression of estrogen receptor (ER), p53, and ErbB2, the 'intrinsic' genetic signatures as defined by microarray studies are more informative classifiers of tumor subtypes.
The more recent microarray studies have benefited from substantial progress in defining the V. vinifera genome in the last five years.
Basal-like tumors were originally defined on the basis of microarray studies, in which their molecular signature suggested similarities to basal cells resident in normal breast epithelium.
Perhaps the biggest statistical challenge that faces microarray studies is the propensity for a high FDR previously defined as false discovery rate caused by multiple hypothesis testing.
A microarray study was undertaken to define the gene expression profile in response to exosome treatment on a global scale.
