Suggestions(5)
Exact(7)
Subsequent microRNA microarray screens have identified several microRNA candidates, such as miR-127, as possible players in early lung development [12].
In addition, unbiased microarray screens have also revealed an increased expression of Wnt target genes, such as matrix metalloproteinase (Mmp) 7, or secreted frizzled-related protein (Sfrp) 2 in IPF [15] [17].
Unbiased microarray screens have recently revealed the overexpression of Wnt target genes, including Wnt-induced signaling pathway protein (Wisp) 1, matrix metalloproteinase (Mmp) 7, or secreted frizzled-related protein (Sfrp) 2, in IPF lungs [16], [17], [22].
Microarray screens have been used to define markers that will distinguish disc cells from other cartilage cells [ 13- 15].
Recently, microarray screens have demonstrated increased IFN-inducible gene (IFIG) expression in peripheral blood mononuclear cells of patients with active SLE.
In the context of human Rhabdomyosarcomas, which result from a chromosomal translocation leading to the expression of a fusion protein, PAX3-FKHR or PAX7-FKHR in which the PAX DNA binding domain is followed by the strong transcriptional activation domain of the FOXO1A (FKHR) factor, a number of microarray screens have been performed on cultured cells (for review see [ 15]).
Similar(53)
Indeed, an unbiased microarray screen has revealed that cyclic stretch can modulate the expression levels of a broad spectrum of microRNA in vitro, possibly contributing to stretch-associated alveolar epithelial cell dysfunction [37].
Multiple studies towards that end, including cytogenetic analyses, but also genome-wide microarray expression screens, have been performed and important players have been identified.
These microarray-based screens have identified 225 down-regulated genes in spl ovules [ 57], 71 and 382 down-regulated genes in dif1 ovules [ 55, 56], and 421 down-regulated genes in coa pistils [ 54].
From pin tools to SGA robots to high-resolution microarrays, deletion collection screens have continually pushed the envelope of high-throughput and genomic technologies.
Microarray comparisons and genetic screens have been undertaken by various laboratories to identify genes that drive wound healing and/or the wound inflammatory response in the embryo and in larvae (Stramer et al., 2008; Campos et al., 2010; Lesch et al., 2010).
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