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High throughput screening of pharmaceutical compound libraries with protein targets, and microarray screening of protein protein interactions for proteomics are examples of applications that require the sensitivity and throughput afforded by this approach.
To identify markers of HVC we used microarray screening of laser capture microdissected samples from HVC and the adjacent Shelf region combined with bioinformatics for a comprehensive analysis of molecular genetic specializations of HVC.
To this end we undertook a large-scale microarray screening of miRNA expression during the process of neural differentiation in order to define expression patterns of miRNAs that can be linked to different stages of neurodevelopment and, subsequently, to specific pathways regulating neurogenesis.
Moreover, this first microarray screening of the effects of Gelsemium s. on neurocytes revealed a significant down-regulation of genes for inflammatory response, olfactory transduction and neuron differentiation.
Recently, early gene expression changes were studied by microarray screening of gastrocnemius muscle from the SOD1 mouse model of ALS [ 74].
In an attempt to shed more light on epigenetically silenced genes in CRC, we identified VANGL2 during a cRNA microarray screening of a panel of CRC cell lines treated with the demethylating agent 5-aza.
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To address these issues, we completed a microarray screen of three zones derived from manually segmented embryonic mouse tibiae.
A global microarray screen of scrapie-infected mouse brains identified a limited number of genes undergoing transcriptional elevation well before the clinical onset of disease.
We identified the glucocorticoid receptor (GR) as a potential regulator of chondrocyte hypertrophy in a microarray screen of primary limb bud mesenchyme micromass cultures.
We also recently identified Papss2 as regulated by TGF-β in a microarray screen of TGF-β-treated mouse embryonic sclerotome [ 36].
PUMA-g is a G-protein-coupled transmembrane receptor that was initially identified in a microarray screen of macrophages activated with TNF-α and interferon-γ [ 29].
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