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Taken together, our microarray results support a role for dTip60 in the control of target genes involved in a diverse array of metabolic and general cellular processes.
Although the influence of indirect effects cannot be discounted and unlisted genes may be down-regulated to undetectable levels, the microarray results support the notion that SYT-SSX2 may predominantly activate rather than suppress genes.
The enrichment analyses and the gene expression microarray results support the idea that SEN analysis of bladder in population-based studies is able to identify biologically meaningful statistical patterns.
The current microarray results support these observations but also showed enrichment of calponin (Contig7933) in lung schistosomula (5.4-fold) and the aquatic/snail stages (egg, 12.8-fold; miracidium, 18.5-fold; sporocyst, 6.2-fold; cercariae, 3.4-fold).
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However, the QPCR showed a log2-ratio identical to the microarray results supporting that this gene is in fact up-regulated.
In addition, microarray results supported (from a molecular point of view) the autophagy process observed in both cell lines.
The microarray results further support this conclusion.
Overall, the QPCR data were broadly consistent with the microarray results, and support the idea that the three pairs of CHATL genes have diverged in their expression patterns despite their high homology.
Based on our microarray results and supported by the primer extension and biochemical analysis we propose the following plausible scenario.
However, the microarray results were supported by the analyses of the effects of extensive long-term ex vivo cultivation of MSC on their proliferation capacity, their morphology, surface marker profile, and differentiation ability.
Furthermore, the 41 genes examined by real time qRT-PCR confirmed the BOTL-5 microarray results and supported a trend towards a proinflammatory immune response to bovine tuberculin in PBMC from BTB-infected cattle.
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