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CW directed all activities, as well as performed immunohistochemical staining, and data mining of public microarray repositories for expression and RFS data.
To examine the role of mRNA stability in determining the dynamics of transcriptional networks in mammalian cells, we scanned expression microarray repositories for time-course datasets that profiled cellular transcriptome in human and murine cells at dense kinetics.
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The increase in publically available microarray repositories provides a tremendous potential for data mining to unravel knowledge of cellular processes.
Summary: Drug versus Disease (DvD) provides a pipeline, available through R or Cytoscape, for the comparison of drug and disease gene expression profiles from public microarray repositories.
Finally, DvD is a recently developed tool providing a pipeline for the comparison of drug and disease gene expression profiles from public microarray repositories.
Inference methods for construction of gene regulatory networks have been extensively developed after genome-wide microarray repositories became publicly available [ 25- 31].
b) Microarray repositories such as Gene Expression Omnibus (GEO) [ 15], ArrayExpress [ 16], Oncomine, Stanford Microarray Database (SMD) [ 17] and Center for Information Biology gene EXpression database (CIBEX) [ 18] were screened for data-sets related to mammalian testis.
Microarray data have been uploaded to the NCBI GEO microarray repository.
The raw microarray data have been deposited in the Gene Express Omnibus microarray repository and are publically available under accession number GSE11498.
Oncomine [ 22, 23] is a cancer microarray repository, containing >18,000 gene expression profiles from a diverse number of microarray studies.
For the selected studies we obtained raw microarray data (CEL files) from public microarrays repositories [13], [14], [19] or from the study authors [16, Vogt, 2006 #1529,]1,].
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