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In addition, it integrates internal and external microarray repositories and provides literature and pathway analysis services.
Additional experimental datasets can be obtained from the microarray repositories and added to the pipeline by the authors as they become available.
Further, to gain insights into their potential physiological function in plants, we have studied their expression at different stages of plant development, across various plant tissues, and under biotic and abiotic stresses using public microarray repositories and via qRT-PCR.
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The raw microarray data have been deposited in the Gene Express Omnibus microarray repository and are publically available under accession number GSE11498.
CW directed all activities, as well as performed immunohistochemical staining, and data mining of public microarray repositories for expression and RFS data.
The microarray datasets and their latest gene chip annotation files were derived from public microarray repositories GNF BioGPS, NCBI GEO and EBI ArrayExpress.
The belief that such wealth of genomic information the community could not afford to lose has led to the development of microarray standards [1], [2] and databases including two major public microarray repositories, Gene Expression Omnibus (GEO) [3] and ArrayExpress [4], in the hope of enabling mining and exploration of newly acquired data space.
Human curators at the two major microarray repositories, NCBI GEO [ 2] and Array Express [ 3], are working to produce enriched resources known as GEO Datasets and the Gene Expression Atlas [ 4], respectively.
In addition to experiments submitted to public microarray repositories, GPX-MEA includes experiments and associated data selected from a survey of over 2500 publications in the field of macrophage immunology and infection.
ProfileChaser [55] searches microarray repositories based on genome-wide patterns of differential expression, and MARQ [56] mines GEO for experiments that generate a differential expression profile that is similar or anti-correlated to an input gene expression signature.
Moreover, one of significant findings in this work is that FT6 gene expression correlates best to clinical PCa progression and metastasis as revealed by public microarray repositories from the NCBI Gene Expression Omnibus.
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