Within these pathways, gene symbols associated with GO, annotated to rat, and present on our microarray platform were identified (total genes: insulin receptor signaling = 37; inflammatory signaling = 141).
Using the high-sensitivity Illumina microarray platform, we identified changes in the human SM cell transcriptome that were induced by tissue biopsy culture based on the explant technique.
van't Veer and colleagues [ 74] used a different microarray platform and identified a 'poor prognosis signature' that included 70 genes involved in regulation of the cell cycle, in invasion, in metastasis, and in angiogenesis.
In previous work we demonstrated the ability of pilot versions of the peptide microarray platform to identify novel ligands for a number of specific protein modules [11], [13] [15].
Previously, we described the first use of a human gene promoter tiling microarray platform to identify genome-wide DNA methylation patterns in a human breast cancer cell line model of metastasis [4].
The single nucleotide polymorphism (SNP) array, a genomic microarray platform, can identify these various ROHs.
We undertook high-resolution DNA methylation profiling with the Affymetrix human promoter microarray platform to identify metastasis-related methylation differences between the 468GFP and 468LN cell lines.
In this study, we conducted a comparative host anemone transcriptome analysis using a cDNA microarray platform to identify genes involved in cnidarian – algal symbiosis.
We deployed an automated high-sensitivity microarray platform to identify genes differentially expressed between aneurally cultured myotubes derived from human SM biopsies by the explant technique and the SM tissue samples.
Moreover, a whole-genome approach using a human gene promoter tiling microarray platform to identify genome-wide and gene-specific epigenetic signatures of breast cancer metastasis to lymph nodes led to functional associations between the methylation status and expression of genes CDH1, CST6, EGFR, SNAI2 and ZEB2 associated with epithelial-mesenchymal transition [ 41].
