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We have provided many ways to visualize and summarize promoter-level microarray or genome-wide epigenomic data.
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This ribosome-centric approach provides more specific quantitation and greater dynamic range than the mRNA-centric technique polysome profiling (coupled with microarray or other genome-wide analysis), although it does not reveal distinct pools of mRNA that can be observed using latter approach.
The 22q11·2 microdeletion was confirmed by standard fluorescence in situ hybridization (FISH) or genome-wide microarray techniques using standard probes and methods, 18, 19 at a median age of 24·2 (range 3·8 66·5) years.
The screen developed has rich potential if extended to include other ion channels or genome-wide microarray analysis, and similar investigation of gene induction by NGF could show nociceptor-specific mechanosensitive channels.
Using microarray technology, genome-wide information about patterns of gene expression during interactions between Arabidopsis or cultivated species and a variety of different pathogens was previously obtained.
Examples of this approach include microarray based genome-wide expression analyses [15] and genotype detection for specific gene [16].
Using DNA microarray technology, genome-wide gene expression profiling was performed on 75 untreated cancer specimens from 64 EAC patients.
Previously, we developed a genome-wide DNA methylation analysis called Microarray-based Integrated Analysis of Methylation by Isoschizomers (MIAMI) using a microarray with genome-wide probes and used for several applications [16], [17].
Additionally, microarray based genome-wide SNP analysis (Affymetrix Genome-wide Human SNP Nsp/Sty 6.0) was performed for donor and recipient for further MHC and genome-wide SNP analysis.
We examined the effects with the noncommercial MCGI (mouse CpG islands) microarray for genome-wide screening the DNA methylation aberrant in induced OSCC mice.
Methylated DNA enrichment is a key step in a microarray based genome-wide methylation profiling study, and even for future high-throughput sequencing based methylome analysis.
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