All microarray data were obtained from the Microarray Innovations in Leukemia (MILE) study, the National Center for Biotechnology Information's Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/) under series accession no.
The microarray leukemia dataset is a subset of 250 samples collected from the Microarray Innovations in Leukemia (MILE) study [ 18] available at Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/) under series accession number GSE13159.
This study is part of the MILE Study (Microarray Innovations In LEukemia) program, an ongoing collaborative effort headed by the European Leukemia Network (ELN) and sponsored by Roche Molecular Systems, Inc., addressing gene expression signatures in acute and chronic leukemias.
At present, an international study (MILE: microarray innovations in leukaemia) is prospectively testing 4000 cases of leukaemia and MDS in 11 centres within the European leukaemia network (ELN, WP13) to define the role of GEP in the diagnostic panel in leukaemia (Haferlach et al, 2006; Staal et al, 2006).
Meanwhile, large multi-centre studies — e.g. the Microarray Innovations in LEukaemia (MILE) study 10 — prepare for a standardised introduction of gene expression profiling in diagnostic algorithms, aiming to translate this novel methodology into clinical routine for the benefit of patients with the complex disorders.
IGF1-R associated gene expression profiles were generated from microarray gene expression data of 86 T-ALL patients from the Microarrays Innovations in Leukemia (MILE) multicenter study.
IGF1-R-associated GEP of an independent set of 86 adult T-ALL samples were generated from raw data obtained from the Microarrays Innovations in Leukemia (MILE) multicenter study (HG-U133 Plus 2.0 and HG-U133 A+B; Affymetrix, Santa Clara, CA, USA) [ 24].
Remarkable advances have been made in genetics and genomics over the last decade due to the rapid technology innovation in microarray and sequencing.
Tissue microarrays are a recent innovation in the field of pathology.
One is rapid innovation in advanced economies.
