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Additional file 4: Figure S1 shows a screenshot of the web page with brief information (a coding gene, the corresponding probe set, GmaAffx.88235.1.S1_at and one microarray expression series, and ten deep sequence samples).
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It has particularly appeared in papers on dimensionality reduction, clustering or classification for microarray expression time-series data (e.g., [ 22- 24]).
The simulation design was influenced by a previously described design for short-term time series microarray expression data [5].
We extract the gene expression observations for all genes on this pathway from the AltGenExpress development series microarray expression data [ 12] downloaded from the ArrayExpress database [ 2].
Using time series microarray expression data in replicate, we have developed a method that identifies a number of temporal scales in addition to the time scale being measured.
We use the microarray expression data of a series of 67 different human tissues taken from ten tissue categories such as nervous, immune system, epithelial and muscle tissues as an illustrative example to demonstrate the strengths of the SOM method in disentangling large heterogeneous data sets.
For purposes of spectral analysis, consider a series of microarray expression values for gene x with N samples of the form: This series can be converted from time-domain, where each variable represents a measurement in time to a frequency domain using a Discrete Fourier Transform (DFT) algorithm.
The time-series microarray expression profiles of the Δ so2426 mutant relative to the parental strain were clustered using Hierarchical Clustering Explorer (HCE) [ 58].
These authors combined two correlation-based approaches [ 36, 40] capable of identifying patterns of correlation across time-series microarray expression data.
Time series of microarray expression profiles of heads of flies treated with PTZ for 12 hrs (beginning phase), two days (latent phase) and seven days (behaviorally expressive phase) showed only down-, not up-, regulatiof of genes; expression of 23, 2439 and 265 genes were downregulated, in that order.
Time-series of microarray expression profiles of heads of male flies at 0 hr and after PTZ treatment for 12 hrs, two days and seven days have previously been described [7].
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