Exact(3)
Although the specific issue of whether CLU is up- or down-regulated in CaP is still controversial [3], [13], [15], [59] [61], confirmatory data supporting our hypothesis that CLU is not only down-regulated in CaP, but also in the most of cancers, can be easily retrieved from the Oncomine web site that collects data from more than 20,000 independent microarray experiments (http://www.oncomine.org).org
To our knowledge CYCD4 2 is absent or shows extremely low expression in other microarray experiments http://www.genevestigator.ethz.ch and therefore its strong association with seed growth here makes it an interesting candidate for control of cell proliferation in developing seeds.
Overrepresentation of co-expressed genes was analyzed with the ORA feature of the PageMan tool, which allows effective comparative analysis of multiple microarray experiments (http://mapman.mpimp-golm.mpg.de/general/ora/ora.shtml; [ 103]) using the TAIR8 Arabidopsis protein set as a control group.
Similar(57)
These efforts include ArrayExpress infrastructure for microarray data (http://www.ebi.ac.uk/arrayexpress), Minimum Information About a Microarray Experiment (http://www.mged.org/Workgroups/MIAME/miame.html), and MicroArray Gene Expression (MAGE) markup language (http://www.mged.org; http://www.omg.org/technology/documents/formal/gene_expression.htm).htm
Microarray characteristics and data have been deposited in the NIH Gene Expression Omnibus (Series accession number: ) according to minimum information about a microarray experiment (MIAME) (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi acc=GSE11264) (Jézéquel et al, 2008).
However, public-domain microarray experiments (see, e.g., http://www.genevestigator.ethz.ch) indicate that the Arabidopsis PAPS3 gene is expressed preferentially during microgamete development and in mature pollen [12].
Thus, in order to systematically study co-occurrence patterns in gene expression signatures, we have generated a repository of published gene expression signatures, PubLiME (published lists of microarray experiments, available at http://bio.ifom-ieo-campus.it/publime) (Finocchiaro et al. 2007).
Detailed methods for microarray experiments are available at http://cmgm.stanford.edu/pbrown/protocols/index.html.html
Study design for microarray experiments satisfied the MIAME guidelines (http://www.mged.org/Workgroups/MIAME/miame_checklist.html).html
For the anther microarray data, relative expression levels were extracted from microarray experiments available at NCBI (Gene Expression Omnibus, http://www.ncbi.nlm.nih.gov/geo/[ 72, 73]).
Finally, this artifact is present in a wide variety of microarray experiments (see supplementary information at http://bioinfo.mbb.yale.edu/~kluger/artifact/all.ppt).ppt
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