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Because microarray datasets comprise tens of thousands of features (genes), they are usually used to test the dimension reduction techniques.
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In order to assess whether therapy resistance might underlie the change of the tumor phenotype toward a mesenchymal/basal phenotype, we collected a cohort of 93 microarray datasets comprising murine xenografts of human tumors before and after hormonal therapies.
Underlying GeneFriends is a Mus musculus co-expression map created from 1,678 microarray datasets, comprising over 20,000 individual samples from previously published experiments.
A publicly available Affymetrix microarray dataset comprising ~24,000 genes was downloaded from AtGenExpress.
To investigate the clinical relevance of our observations, we analyzed a microarray dataset comprising 285 primary ovarian cancer patient specimens [ 19].
Expression of cPLA2 α was investigated in a second gene expression microarray dataset comprising 295 breast cancer patients from The Netherland Cancer Institute (van de Vijver et al, 2002).
Recently, we reported in Nagalla et al. [ 36] the discovery of three biologically distinct immune gene signatures, or metagenes, in a large microarray dataset comprising 1,954 breast tumor expression profiles.
Data for many probesets in a given expression microarray dataset are comprised of noise but little or no biological signal.
Four microarray datasets from different institutions comprising 265 advanced stage tumors were uniformly reprocessed into a single training dataset, also adjusting for inter-laboratory variation ("batch-effect").
The dataset samples included in the compendium were grouped into 6 Experiment Sets as follows: 1) Breast Cancer: comprised whole-genome microarray datasets of breast tumors; 2) Normal Breast: comprised whole-genome microarray datasets of normal tissue from invasive ductal or lobular breast carcinomas.
These cohorts comprise available microarray datasets for medically untreated node-negative breast cancer which have used metastasis-free survival (MFS) as an end point.
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