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Data were obtained from a microarray database (http://www.ncbi.nlm.nih.gov; accession number GSE19024; Wang et al. 2010).

Data were obtained from a microarray database (http://www.ricearray.org/expression/meta_analysis.shtml; accession number GSE21396; Cao et al. 2012).

Microarray data for indica rice varieties Minghui 63 and Zhenshan 97 were collected from a microarray database (http://www.ncbi.nlm.nih.gov/; accession number GSE19024), which covers 28 tissues and organs representing the entire life cycle of rice (Wang et al. 2010).

To ascertain which MAP kinase cascade gene had high expression level in leaf tissues, a genome-wide microarray data from 28 tissues collected throughout the life cycle of two indica rice varieties in the microarray database (http://www.ncbi.nlm.nih.gov/; accession number GSE19024; Wang et al. 2010) was analyzed.

The microarray data have been submitted to Stanford Microarray Database (http://smd.stanford.edu/cgi-bin/login.pl) and Gene Expression Omnibus (GEO) (www.ncbi.nlm.nih.gov/geo/) under the accession number GSE22876.

Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo), ArrayExpress (http://www.ebi.ac.uk/arrayexpress/), Stanford Microarray Database (http://smd.princeton.edu/), and PubMed (http://www.ncbi.nlm.nih.gov/pubmed) are comprehensive databases for gene expression.

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We used UNC Microarray Database (https://genome.unc.edu/) to perform the filtering and pre-processing.

We explored indirectly the possibility that gcr2, gcl1 and gcl2 might possess conditional phenotypes by examining the stress-specific expression profile of GCR2, GCL1 and GCL2 genes in the Genevestigator Arabidopsis thaliana microarray database (https://www.genevestigator.ethz.ch/) [26].

Finally, the differential expressions of mRNAs were validated by Oncomine (a public cancer microarray database; https://www.oncomine.org/).org/

Normalized gene expression data from NKI and UNC cohort were obtained from pubic Merck website (http://www.rii.com/publications/2002/nejm.html) and UNC microarray database (https://genome.unc.edu), respectively.

Microarray image files were analysed with GenePix Pro 4.1 (Molecular Devices, Sunnyvale, CA, USA) and loaded into the UNC-CH Microarray Database (https://genome.unc.edu/), and are available in the Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo) under the series numbers GSE8465.

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