Prior co-expression analysis of biotic stress microarray data had uncovered the regulation of SID2 by WRKY28 and the regulation of SA biosynthesis component PBS3 by WRKY46[ 25].
In addition to confirming expression of genes with known roles in unc-4 GFP unc-4 GFPon differentiation and function, the motorarray data also uneuronedifferentiationands functiongenes governing these events.
By applying the computational analysis on human microarray data, we uncovered a unique expression pattern of TACSTD2 in breast cancer, and experiments confirmed TACSTD2 show bimodal behavior in breast cancer cell lines, further, our perturbation study suggest a potential bistable mechanism is involved.
In a comparative transcriptomics approach, I examine here if mining of the available fly [ 9] and human [ 6- 8] microarray data could uncover potential mechanism of PTZ action in DS.
Importantly, these questions did not ask students to perform any computations, focusing instead on how statistics are used to interpret microarray data to uncover the biological meaning of the results.
Indeed, although microarray data can help uncover new features into cancer cell biology, cancer prognosis cannot solely rely on microarray data without taking into account the clinical characteristics of the patients.
As a global reduction of RNA synthesis was expected on accumulation of DNA helical stress (Gartenberg and Wang, 1992), we used qRT PCR to determine the absolute value of transcript levels in our strains, as well as to validate the differential response of the chromosome flanks uncovered by the microarray data.
The interpretation of these patterns matched the information contained in the pairwise comparisons of the microarray data, which finally allowed us to uncover the genes that are regulated by both Hsp90 and p23.
Based on EST, protein profile and microarray data, we performed integrated data mining to uncover signature embolic pathways in the endosperm.
