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While microarray data submissions are encouraged by regulatory agencies and widely accepted in toxicogenomic research [ 2, 13], the third phase of the microarray quality control project (MAQC-III also known as SEQC) recommended further validation using different study designs [ 1, 25].
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Microarray data submission for human arrays is MIAME compliant.
The microarray data submission for human arrays is MIAME compliant.
Details (gender, weight, age, family relationship) of all animals are on record and are included in our microarray data submission to GEOS.
Though many high-impact journals now mandate that all HTP data and code associated with a publication be made open-access, this requirement is not universal, and sometimes the same journal will require microarray data submission, but not proteomic data.
All the raw data has been submitted and accepted to ArrayExpress (EBI) database in line with the MIAME principles of publishing microarray data (submission accession number: E-MEXP-1068).
We are thankful for the help of Patrick Chapman for contributions in tabulating microarray data for database submission.
As industry and regulators wrestle with the intricacies of microarray data formats and submission, even more complex challenges loom: the data produced by proteomics and metabolomics research.
We thank Mr. Kazunori Yamada for help of manuscript preparation and submission in BMC Genomics Dr. Shin-nosukee Takeshima for submission of microarray data in the NCBI's Gene Expression Omnibus and kind help of preparation of manuscript; Mrs. Mayuko Jimba for help of manuscript preparation; and other members of the Viral Infectious Diseases Unit, RIKEN, for kind help and suggestions.
All microarray data was deposited as MIAME-compliant data submissions GSE31378 in the Gene Expression Omnibus.
The exercise served as a practice run to help the FDA understand the format and content of future drug submissions containing microarray data.
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