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Applying appropriate error models and conservative estimates to microarray data helps to reduce the number of false predictions and allows one to focus on biologically relevant observations.
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The linkages between the phenotypes (the clinical parameters) and the genotypes (the microarray data) help to formulate new hypothesis and aid to obtain new insights into the complex mechanisms of diseases.
designed and helped analyzing the microarray data, and helped with writing; LY. performed the ChIP experiments; JR. helped with the animal experiments and cell stimulations; AB. helped with the animal experiments, cell stimulations and writing; WE. was involved in the planning and execution of the project, and helped with writing; CIES.
Experimental evidence has confirmed the translation of several small HPs in R. felis [40] and future microarray data will help lend resolution to this poorly understood characteristic of rickettsial genomes.
RZNV analyzed microarray data and helped write the manuscript.
CHK performed the analysis of microarray data and helped to draft the manuscript.
LR performed the statistical analysis of the microarray data and helped draft the manuscript.
SS did clustering analysis of microarray data and helped with other statistical analyses.
NRS collected and normalized the microarray data and helped with the design and interpretation.
JA processed the microarray data and helped for the network construction.
CW participated in study design, research trial, EBI submission of the microarray data and helped prepare the manuscript.
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