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The linkages between the phenotypes (the clinical parameters) and the genotypes (the microarray data) help to formulate new hypothesis and aid to obtain new insights into the complex mechanisms of diseases.
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Applying appropriate error models and conservative estimates to microarray data helps to reduce the number of false predictions and allows one to focus on biologically relevant observations.
designed and helped analyzing the microarray data, and helped with writing; LY. performed the ChIP experiments; JR. helped with the animal experiments and cell stimulations; AB. helped with the animal experiments, cell stimulations and writing; WE. was involved in the planning and execution of the project, and helped with writing; CIES.
Experimental evidence has confirmed the translation of several small HPs in R. felis [40] and future microarray data will help lend resolution to this poorly understood characteristic of rickettsial genomes.
First, we analyzed Arabidopsis microarray data to help identify the involvement of the WRKY TFs in jasmonate signaling.
More interestingly, including microarray data can help in determining if two proteins bind to ESR1 at the same time by looking at the correlation of their expression patterns.
Indeed, although microarray data can help uncover new features into cancer cell biology, cancer prognosis cannot solely rely on microarray data without taking into account the clinical characteristics of the patients.
Analyses of the merged data set by clustering or correlating the protein and microarray data can help identify candidate targets when changes in expression occur at both the gene and protein levels.
Although most expression signatures still can't be interpreted or linked to biologic effects, officials at both the FDA and the EPA express optimism that the use of microarray data could help them better protect public health.
As bi-allelic inactivation of tumour suppressor genes often involves loss of the second copy of the genomic region harbouring these genes, integrating data from using NMD microarrays with whole genome CGH microarray data may help in order to focus the search to deleted chromosomal areas.
RZNV analyzed microarray data and helped write the manuscript.
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