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Meta-analysis of microarray data combines independent microarray expression studies to create very large datasets with greater statistical power [ 1, 2].
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The microarray data, combined with in vivo experiments presented here, confirmed the involvement of HU in the SOS and the osmolarity/supercoiling responses [20], [21], [24], [33].
Prosecutor uses DNA microarray data combined with functional annotations to infer putative gene functions.
The analysis of our DNA microarray data combined with the data from databases, revealed new operons and pathways which might be regulated by PdhR.
GeWare is a data warehouse that stores Affymetrix GeneChip® microarray data combined with manually added annotations and data from public databases like GO, Ensembl, LocusLink and NetAffx [ 28, 53- 55].
A further evolution can be seen in studies in which two omics data sources are simultaneously considered, in most cases microarray data combined with proteomics or array CGH data.
The BMDExpress software is designed to perform a stepwise analysis on dose-response microarray data that combines standard BMD methods with GO classification analysis.
In general high individual variability was observed in the microarray data, which combined with a limited number of samples (n = 3-4), appear to have contributed to moderate levels of statistical significance for differential regulation.
Meta-analysis of microarray data, sometimes combined with other types of data – proteomics, co-precipitation, literature, yeast two hybrid – has proven valuable for model organisms including bacteria [ 2], nematode [ 3], human [ 4, 5], chimpanzee [ 6], mouse [ 7], rat [ 8] and yeast [ 9- 11].
Therefore, we utilized a previously described microarray data set combining method (Distance Weighted Discrimination) to create a large validation test set of over 300 tumors, and used it to validate a newly derived gene list for breast cancer prognostication and prediction.
6, 17 Hierarchical clustering techniques are extensively used in microarray data analysis, which combines all data points into a single set which are placed adjacent to each other in the feature space.
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