We note that molecular data, not available for all of the microarray samples, can differentiate the DEV2 and DEV3 time points: the relative abundance of double stranded breaks and covalently closed circular intermediates of the IES excision pathway is different [ 51].
Recent microarray studies on C2C12 cells, mouse myoblasts that can differentiate into myotubes, have afforded a broad molecular description of myogenesis and identified sets of genes that display transcriptional variations in expression between proliferating and differentiating cells [ 13- 16].
In addition, RNA-Seq provides single nucleotide resolution for mRNA, therefore, it can differentiate gene isoforms (transcripts), whereas microarray is often not able to identify isoforms because it uses probes to detect mRNA levels.
To test if similar signatures exist in breast cancer, we applied the prediction analysis of microarray algorithm to interrogate our datasets for genes that can differentiate between African-American and European-American breast cancer patients.
In addtion, thanks to the digitalized dynamic range of read coverages, PatternCNV can differentiate high versus low amplifications, while microarrays are limited by the saturation of probe hybridization signal.
In agreement with previous microarray studies, the present study has demonstrated that IGFBP3 is overexpressed in pancreatic cancer and can differentiate cancerous from benign tissue (Iacobuzio-Donahue et al, 2002; Logsdon et al, 2003; Iacobuzio-Donahue et al, 2003a; Grutzmann et al, 2004; Missiaglia et al, 2004; Laurell et al, 2006).
Fibrocytes can differentiate into myofibroblast.
These are tastes which the palate can differentiate without smell.
3. Empathy can differentiate your practice.
