More recently, a sRNA microarray approach allowed researchers to discover that 6S RNA is implicated in intracellular multiplication [19].
Secondly, the improved microarray approach allowed the additional detection of several differentially expressed genes, which are potentially important targets for further research.
Comparative analyses performed through a microarray-based approach allowed identification and characterization of large mobile genetic elements that seem to be exclusive to South American strains.
Moreover, the microarray approach provided allowed the discovery of a set of new potential chicken mature oocyte and chicken granulosa cell markers for future studies.
This approach allows a clear discrimination between microarray expression profiles of persistent AF patients respect to a control population.
Alternatively, species-specific quantitative real-time PCR (qPCR) analysis or cross-species hybridization of microarrays have been attempted [ 2, 3], but neither approach allows for a large-scale probing of the transcriptomes from two species.
In addition, our approach allows for the first time the assessment of the fidelity of in situ RNA microarray synthesis and will have an important impact on the emergence of high-density complex RNA array technology.
Unlike DNA microarray technologies, which is limited to the analysis of genes previously characterised and assigned to an array, the SAGE approach allows for the detailed analysis of expression patterns of uncharacterised genes as well as of known genes.
Although such an approach allows the most efficient analysis to classify tumors, Q-RT-PCR has some advantages over microarrays since it provides accurate, reproducible and sensitive quantification of mRNAs.
Bacterial microarrays enable profiling of accessible carbohydrate structures and screening of their recognition by host receptors, also providing information on binding avidity, while the QCM approach allows determination of binding affinity and kinetics.
