After quantitation of expression level of each probe set in all microarrays analyzed, the SAM algorithm [ 122] was used to identify probe sets displaying significant differential expression when comparing the treat samples to it controls.
Microarrays analyzing the RNAi-mediated depletion of hnRNP A1 showed an increase and decrease of PDCD4 and BAG4 mRNA levels, respectively; the proteins of which are thought to have anti-apoptotic effects [13], [14].
MW conceived the project, designed the study, performed microarray experiments, analyzed the microarray data, performed the quantitative Real Time PCR experiment, performed statistical analyses and drafted the manuscript.
CHK designed and developed the miRNA microarrays, performed microarray experiments, analyzed the miRNA data analysis and wrote the manuscript.
KJ designed the microarray experiment, analyzed the differentially expressed genes and drafted the manuscript.
SJW performed microarray hybridizations, analyzed the data and wrote the manuscript.
KVP carried out microarray experiments, analyzed the transcriptome data and drafted the manuscript.
FC designed the experiment, collected the samples, performed the microarray hybridization, analyzed the data and wrote the manuscript.
MK constructed the microarray chip, analyzed the results, performed the qRT-PCR analysis, and wrote the manuscript.
YY and SP performed the microarray experiments, analyzed the gene expression data, and helped write the manuscript.
