In our microarray analysis, we observed high expression of pluripotency-related genes involved in the core hESC regulatory circuitry, including OCT4, SOX2, and NANOG, as well as CRYPTO 1 and 3, LCK, and HESX1.
In our microarray analysis we observed that this gene was downregulated in tumoral samples.
Ancona et al. performed a microarray analysis and observed that ACAT1 was downregulated in tumoral tissue, comparing to normal mucosa [ 33].
By microarray analysis, we observed in mono-transgenic mice a downregulation of members of the S100 protein family, small calcium-binding proteins responsible for a wide range of intra- and extracellular functions [ 39].
Also, with one exception (OSMR), the selection threshold of at least five-fold higher expression in cartilage tissues as compared with the average expression among all non-cartilage tissues imposed for the microarray analysis, was observed.
In our cDNA microarray analysis, we observed that some cell cycle-related proteins were significantly altered in selenite-treated NB4 cells, which indicated that selenite might have a role in cell cycle regulation.
From gene expression microarray analysis we observed 654 genes that were upregulated 2-fold or more in a minimum of four out of the six CCA cell lines after epigenetic drug treatment (5-aza-2′deoxycytidine and trichostatin A).
Using gene expression microarray analysis, we observed that Cdc5L downregulates the expression and splicing efficiency of genes involved in mitotic progression and DNA damage repair such as dynein, dynactin and RAD1.
To elucidate the global cellular pathways that are altered in PC cells upon downregulation of the mutant Kras allele, we conducted microarray analysis and observed that most of the genes differentially expressed in the Kras-Scr compared with the shKras cells were associated with cell proliferation, motility and metastatic behaviour of tumour cells.
In this study, we performed a microarray analysis to observe the human placental trophoblast-like BeWo cells response to lipopolysaccharide (LPS) from periodontopathogen Aggregatibacter actinomycetemcomitans (Aa), in order to investigate the molecular basis of mechanisms for periodontitis-associated LBW.
