It remains to be determined if nonadditive expression detected for other genes in our microarray analysis might be explained by specific homoeologous rearrangements in the lines, since the microarray platform we employed was unable to distinguish between related transcripts.
Overall, these results were consistent with hypothesis 2, which claimed that the host gene expression of animals with MCF was affected in a manner that could be detected by microarray analysis and that could explain the disease phenotype without all dysregulated cells being infected.
Taken as a whole, these results were consistent with one of our hypotheses, which claimed that the host gene expression of animals with MCF was affected in a manner that could be detected by microarray analysis and that could explain the disease without all dysregulated cells being infected.
This high variability might also explain why their microarray analysis of OA chondrocytes revealed the downregulation of an array of genes involved in cytokine signaling including IL-1β, IL-8 and leukemia inhibitory factor [22], whereas a recent study showed upregulation of these same genes in OA [15].
Microarray analysis identified several potential genes whose altered expression could explain the disturbed cell lineage phenotype in the Car9-/ gastric mucosa.
However, no significant differences in β-catenin mRNA levels were observed between the cell groups, explaining why β-catenin was not identified in microarray analysis.
We utilized whole genome microarray analysis and identified functional categories of genes affected by this herbicide that help explain dicamba's mode of action.
Microarray analysis revealed several genes involved in developmental processes and cell differentiation, which could explain the cell lineage disturbance in the gastric epithelium of Car9-/ mice.
This discrepancy may be explained that C/EBP regulated genes are not yet up-regulated at the chosen time point in our microarray analysis.
performed microarray analysis.
M.J.A. performed the microarray analysis.
