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Data derived from our microarray analyses support this observation.
In addition, changes identified in these microarray analyses support a role for more generalized transcriptional dysregulation in toxicity of expanded repeat RNAs.
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Indeed, microarray analyses supports the hypothesis that intronic miRNAs are usually expressed in coordination with the host gene mRNA in human tissues [ 4, 5], strongly suggesting that co-transcription from the host gene promoter is the most common transcriptional mechanism under normal conditions.
Microarray analyses also supported these findings; for example, many of the known virulence associated genes in pathogenic Neisseria sp., were also found to be present in the closely-related non-pathogen Neisseria lactamica [4].
Expression ratios for individual genes were examined by microarray analyses (see Supporting Information, Table S1).
Microarray analyses were supported by the FUGE Platform for Microarray Technology (Norwegian Microarray Consortium, NMC, microarray.no), funded by the Norwegian Research Council, and this study was supported by The Norwegian Cancer Society.
Global transcriptional profiling with microarray analyses further supports the hypothesis that TSPY exerts pro-growth and proliferative functions in the cell cycle progression of its host cells.
Microarray analyses were partially supported by the Vermont Genetics Network through Grant Number P20 RR16462 from the INBRE Program of the National Center for Research Resources (NCRR), a component of the National Institutes of Health NIHH).
A new genome browser based on the Google map engine, called the X::Map Genome Browser [ 5], contains genomes of three mammalian species and is specialized for supporting microarray analyses based on the Affymetrix platform [ 6].
AA provided bioinformatics support of microarray analyses.
Noticeably, cDNA microarray analyses of different oligosaccharide transporters support that NCFM is capable of utilizing a wide range of carbohydrates including known prebiotics, such as fructooligosaccharides (FOSs), galactooligosaccharides (GOSs), and potential prebiotics, for example, cellobiose [ 9, 10].
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