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The microarray analyses shown in Figure 4 were performed on samples after 24 hours of A-928695 treatment to assess the transcriptional changes that occur as a direct result of this pathway inhibition seen in Figure 5A.
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Furthermore, microarray analyses showed that the expression of OS-related genes in the mouse brain was also changed.
DNA microarray analyses showed that 396 genes (229 up-regulated and 167 down-regulated) were differentially expressed in the mutant MT-1 compared to WT.
Pathway specific microarray analyses showed that in addition to RANTES and IP-10, mycobacteria infected CFP10-DCs showed reduced expression of many Th1 promoting chemokines and chemokine receptors.
DNA microarray analyses show that the evolved and ancestral viruses affect the global patterns of host gene expression in radically different ways.
Real-time RT-PCR and microarray analyses showed significantly decreased Cyp17a1 expression (∼70%) in both siRNA1- and siRNA2-transfected MLTCs (Figure 2).
These observations were confirmed by microarray analyses showing that the gene expression profile characteristic of hESCs (high Oct-4, Nanog, Sox2, Cripto and Nodal, etc).
Fluorescence in situ hybridization of tumors selected on the basis of elevated PTK6 signal intensity in microarray analyses showed an increase in the number of hybridized signals with the PTK6-specific probe (Figure 7B).
Microarray analyses show that the absence of PKBα in early thymocyte subsets modifies the expression of genes known to be involved in pre-TCR signaling, in T cell activation, and in the transduction of interferon-mediated signals.
Microarray analyses showed that pro-inflammatory cytokines, including TNF, induce distinct gene expression programs in different endothelial cell types [8], [9]; this indicates that the endothelial cell type should be carefully chosen for an in vitro model of CM.
A study using microarray analyses showed that gene expression pattern associated with mTOR is suppressed upon aging in the heart of Fischer 344 rats [18], suggesting that mTOR pathway is down-regulated in aging.
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