Mechanisms of mammalian stress erythropoiesis are of importance in anaemic responses and expression microarray analyses demonstrate that Cldn13 is the most abundant Claudin in spleen from mice infected with Trypanosoma congolense.
In fact, our microarray analyses demonstrate that knockdown of PML is associated with a network of genes involved in chronic inflammation-related diseases, such as Rheumatoid arthritis and Atherosclerosis.
Additionally, microarray analyses have demonstrated that siRNAs with only partial complementarity to the 3' untranslated region of mRNAs can cause reduction in the RNA levels of a large number of transcripts, a phenomenon termed "off-target" effects [39], [40].
The same microarray analyses also demonstrated that there was increased expression of the 50 survival-associated genes in ODG and OAC tumors compared to normal brain tissue [ 7].
In addition, the reproducibility of the microarray analyses was demonstrated by the inclusion of patient serum reactive with multiple citrullinated peptides and a mixture of monoclonal antibodies to citrullinated proteins (Additional file 1: Figure S2).
