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As each market is different, the introduction of micro projection technology into other territories is likely to be dictated by the various factors that influence each market".
Here we demonstrate the fabrication of monolithic micro-systems with controlled 3D internal geometry and embedded 3D microstructures using a mask-less micro projection lithography technique designed to coexist on routine epi-fluorescence microscopes.
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Spun off from the highly respected Swiss Federal Institute of Technology in 2008, Lemoptix produces MEMS-based micro-projection technology to enable tiny, low powered projection displays to be embedded in mobile phones, HUDs and other wearables so that content can be displayed on a nearby surface or projected within the device itself, bypassing the typical limitations of physical displays.
However, in our micro-projection coating, a freeze step is not only more technically demanding, but has the potential to reduce the mechanical integrity of the coated layer.
A dose of 55±6.0 ng delivered intracutaneously by micro-projection array was sufficient to produce a maximal virus neutralizing serum antibody response at day 28 post vaccination.
Micro-projection arrays dry-coated with vaccine material (Gardasil®) delivered to C57BL/6 mouse ear skin released vaccine within 5 minutes.
The Nanopatch™ is a micro-projection array with uniquely dense projection packing (>20,000/cm2) and short projections (110 µm in length).
Here we investigate a novel dry-coated densely-packed micro-projection array skin patch (Nanopatch™) as an alternate delivery system to intramuscular injection for delivering an alum adjuvanted human papillomavirus (HPV) vaccine (Gardasil®) commonly used as a prophylactic vaccine against cervical cancer.
Use of dry micro-projection arrays (Nanopatch™) has the potential to overcome the need for a vaccine cold chain for common vaccines currently delivered by needle and syringe, and to reduce risk of needle-stick injury and vaccine avoidance due to the fear of the needle especially among children.
This paper demonstrates effective coating and release of an alum containing vaccine Gardasil® from a novel micro-projection array patch (Nanopatch™) designed to deliver vaccine directly to about 50% of the abundant skin antigen presenting cells [10], for efficient induction of a virus neutralizing antibody response.
The Nanopatch™ design used in this study utilizes a 58×58 array of micro-projections 110 µm high, and 30 µm in base diameter, with a spacing of 70 µm between projection centers (see Figure 2).
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