The provision of chromosomal coordinates for the vast majority of coding region micro-lesions in HGMD is now complete.
Such fine-scale detection could contribute to the improvement of prognosis of cancer patients by identifying micro-lesions in the early phases of primary and metastatic cancers.
Although these probes have been useful in macroscopic imaging, the specificity and sensitivity of these methods must be improved to enable them to detect micro-lesions in the early phases of cancer, resulting in better treatment outcomes.
Considering the advantages of two-photon microscopy described above, we propose that this technique, in combination with fluorescence probes that are safe to use in the human body, could be applied to detection of micro-lesions in clinical settings, for example, carcinoma in situ, remaining cancer cells on the resection borders of tumor specimens, and in early phases of lymph-node metastases.
According to this model, highly frequent repetitive movements cause micro lesions that accumulate in the affected musculoskeletal structures and lead to movement-related pain.
Micro lesions are commonly observed in the reproductive tract of sexually active young women [41] and fibroblasts are widely distributed immediately below normal epithelial surfaces (PS unpublished results for premenopausal human cervix; see [30], [42] for human palatine tonsil).
First, immunotherapy is expected to contribute toward cancer therapy especially in the early stages or in the prevention of recurrence, in which cancer sites, the so-called "micro lesions," are undetectable by imaging modalities.
In the contralateral hemisphere, radiogenic micro-lesions of blood vessels were rapidly repaired, in agreement with previous studies [9], [10], [29].
As shown in Panels A-D, only micro-lesions of tumors were observed, as if the tumors were in dormancy.
Who, after refusing medication for years, lost his vision and suffered micro-lesions on his brain.
Regarding potential etiologic factors in the case described excessive workout during a period of rapid bone growth repetetively creating bony micro-lesions of the bone and causing a disturbance of hydrostatic pressure might have contributed to the development of UBC.
