With the aid of this technology, the adipose tissue is micro-fragmented and washed until free of pro-inflammatory oil and blood residues.
Forty patients, affected by diffuse degenerative chondral lesions, were treated with autologous and micro-fragmented adipose tissue between 1st January 2014 and 31st December 2014.
In conclusion, our results point to autologous and micro-fragmented adipose tissue injection as an innovative and safe approach for the treatment of diffuse degenerative knee chondropathy.
The results of this study show the safety and feasibility of using autologous and micro-fragmented adipose tissue in patients affected by diffuse degenerative chondral lesions.
The 1-year safety and outcome of a single intra-articular injection of autologous and micro-fragmented adipose tissue in 30 patients affected by diffuse degenerative chondral lesions was evaluated.
The aim of this retrospective study is to evaluate the 1-year safety and outcome of a single intra-articular injection of autologous and micro-fragmented adipose tissue in patients affected by diffuse degenerative chondral lesions.
The main finding of this retrospective study is that autologous and micro-fragmented adipose tissue graft is a safe adjuvant for the treatment of diffuse degenerative chondral lesions.
Since the micro-fragmented fat is autologous, minimally manipulated and widely used in other surgical fields (i.e. lipofilling), safety was assessed just by evaluating local adverse events, such as fever, infections, and excessive swelling of the knee.
The injected micro-fragmented adipose tissue has been extensively studied and characterized in vitro by other authors (Bianchi et al. 2013; Ceserani et al. 2016; García-Contreras et al. 2015).
In this context, micro-fragmented adipose tissue could act as a natural "bioreactor" providing cushioning and filling and stimulating the natural regenerative properties of the tissue itself.
Fig. 2 Box plot of VAS pain, Tegner Lysholm knee, IKDC subjective and total KOOS pre-operatively (t0) and at 12 months (t12) after micro-fragmented adipose tissue injection.
