He needs us to know how he sees the tragicomic and macro-micro contrasts of his life and the world.
Previous preclinical studies have shown that grey-scale ultrasound measurements of micro bubble contrast agent flow can be used to investigate tumor angiogenesis [ 19- 23] to estimate the effects of antiangiogenic tumor therapy [ 19, 27- 36].
Second generation ultrasound micro-bubble contrast agents such as Sonovue showed superior safety profiles to CT or MRI contrast agents [ 14].
Intravenous administration of micro-bubble contrast material represents a useful complement to conventional US and is increasingly used for various indications in abdominal imaging (e.g., for the differential diagnosis of focal liver lesions and for the characterization of renal cysts).
The use of micro-bubble contrast agents facilitates the differential diagnosis of nodes ≥5 mm in size by identifying additional vessels and demonstrating VP in more detail[ 47 ].
Intravascular ultrasound (IVUS) has also been shown to map out areas perfused by vasa vasorum but it relies on the injection of micro-bubble contrast agent [ 17].
However, even using micro-bubble contrast, some lesions such as von Meyenberg complexes, can still be difficult to differentiate from metastases[ 23 ].
Typically, following the injection of micro-bubble contrast, liver metastases show rim enhancement or are iso-enhancing in arterial phase and are hypo-enhancing in both venous and delayed phases of imaging.
US guidance remains the optimal, quickest technique for applicator placement but monitoring has become more sophisticated with micro-bubble contrast-enhanced US, multi-planar, multi-slice or preferably co-registered 3D computed tomography or magnetic resonance (MR).
Whether he's tackling politics (The West Wing), tech prodigies (The Social Network) or media (The Newsroom), he meshes micro with macro, contrasting dense information with recurrent human themes: power, morality, control.
In contrast, micro array analysis performed at 48 hpf reveals the opposite pattern: Genes down-regulated at 24 hpf are up-regulated at 48 hpf in the presence of As3+.
