The ability to maintain these elevated levels of IL-10 is of particular interest, and it must be established whether they can be sustained over a longer period (with greater age), and to establish whether ablation or sequestering of endogenous IL-10 in ABIN1[DN485] mice would further exacerbate the observed pathology in this and previous studies.
Since the lymphoid tumors that arise in Tax mice cause significant bone loss (osteolysis) [15], [16], we hypothesized that crossing Arf-/ mice (prone to accelerated bone remodeling) with Tax mice (prone to osteolytic malignancies) would exacerbate tumorigenesis and tumor mediated osteolysis.
Since the TLR-4 pathway mediates the hepatic response to invading bacteria, we hypothesized that the combined effects of sepsis and feeding WD on TRL-4 signaling would exacerbate hepatic inflammation in septic mice.
In addition, we tested whether feeding mice a high fat diet, which also impairs glucose regulation, would exacerbate the impairment caused by rapamycin.
We therefore have analysed whether an increase in mitochondrial derived oxidative stress in response to heterozygous deletion of superoxide dismutase (Sod2+/-) would exacerbate aging phenotypes in telomere dysfunctional (mTerc-/) mice.
The first experiment utilized hypocretin knock-out (HCRT-ko) mice with the expectation that deletion of both HCRT and its target neurons would exacerbate narcoleptic symptoms.
To understand whether a diet high in fat would exacerbate or counterbalance this lean phenotype, we fed adult WT mice the HFD (containing 60% calories as fat) supplemented with vehicle or 500 mg/kg/day DEHP.
The seizure sensitivity of the Tecta mice meant it was not possible to examine whether exposure to high noise levels would exacerbate the observed structural effects of the mutations.
Rising defaults would exacerbate the damage.
Such actions would exacerbate the economic downturn.
