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We hypothesize that administration of leptin to Lepob mice would cause weight loss, decrease gallbladder volume, and change gallbladder genes related to gallbladder motility, nucleating factors, and lipid metabolism.
We initially hypothesized that overexpression of PeriA in Tg mice would cause increased storage of lipid in adipose tissue and promote an obese phenotype.
However, once Runx3 expression was induced, Runx3 would not only repress ThPOK (Egawa and Littman, 2008; Setoguchi et al, 2008) and Cd4 gene expression (Taniuchi et al, 2002; Sato et al, 2005), but Runx3 would also re-activate Cd8 gene transcription (Taniuchi et al, 2002; Sato et al, 2005; Egawa et al, 2007) which, in 4in8 mice, would cause re-expression of Cd8-encoded CD4 proteins.
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The hypothesis was that co-injection with prostate specific antigen (PSA), which is highly immunogenic in mice [16], would cause a T cell mediated immune attack on the PSA/luciferase transfected cells and therefore result in elimination of luciferase expressing cells.
In this scenario, occasional mice would have extreme beta cell proliferation compared with their peers because of intrinsic differences caused by some unidentified variable.
And to allay a fear I read somewhere, no, I really didn't find that pushing one of the 12 buttons would cause the mouse to move a great deal, if at all.
In September 2014, Disney filed an official opposition, arguing the mouse's black ears, black face, white eyes and white mouth would "cause confusion" among consumers, being "nearly identical in appearance, connotation and overall commercial impression to Disney's mouse ears".
That would cause a sensation.
This would cause grave harm to clients.
Doing so would cause another shutdown tailspin.
That would cause a tsunami of opposition.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com