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Therefore, mice with total myocardial creatine >140 nmol/mg protein were excluded from all subsequent experiments.
The mouse anti-LG13 pAb was raised after immunization of BALB/c mice with total L. donovani (strain LG13) extracts.
30 Studies in mice with total KCNQ4 knockout showed a more rapidly progressive hearing loss in comparison with those heterozygous for the dominant negative mutation.
We also observed that treating mice with total extracts of medicinal plants increased the activity of all antioxidant enzymes examined, including SOD, CAT, GST and GSH.
In mice with total disruption of the gene encoding for the VDR, renal renin mRNA levels are threefold higher than in wild-type mice, and plasma ANG II is increased 2.5-fold.
To investigate the effect of the deletion of Foxp3+ Treg in a situation of intact immunologic homeostasis at the mucosal barrier in the intestine, we reconstituted Rag1−/− mice with total CD4+ T cells obtained from Foxp3-GFP-DTR mice and administered DTx (or PBS control) to those reconstituted animals between days 14 and 18 every other day.
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Untreated (UT), NSCT, IC GT-treated Twi mice, Twi mice transplanted with total BM from wild-type (WT) tgGFP mice as well as UT, NSCT and BMT WT age-matched littermates were used as controls to compare the outcome of combined versus single treatments (Supplementary Material, Fig. S1).
Twenty-two different activity parameters were measured for each mouse, with total distance travelled, total activity, rearing time and total mobile counts considered the best parameters for monitoring behavioural activity.
Moreover, tumours from mice injected with CD44+CD24− cells phenotypically resembled tumours removed from mice injected with total LNCaP cells, indicating that CD44+CD24− cells can give rise to the heterogeneous population present in tumours derived from the LNCaP cell line.
The tumor burden in the mice treated with total plant RNA alone was less than that in the water-treated mice, suggesting that plant RNA alone may have a therapeutic effect.
Tumours from mice injected with CD44+CD24− cells recapitulate the spectrum of cells obtained from tumours from mice injected with total LNCaP cells, including CD44+CD24−, CD44−CD24+, and CD44−CD24− cells.
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