Sentence examples for mice with sustained from inspiring English sources

The CRF-OE mice with sustained elevated levels of CRF and corticosterone and hair loss as seen in the present and prior studies [11] have good face and construct validity as a relevant model for alopecia and therefore provide a unique opportunity to unravel pathways in chronic stress-related hair loss.

Phosphorylated p38 was present after wounding, with peak levels on days 1 and 2, declining to near baseline by day 7 in db/db mice with sustained hyperglycemia.

We investigated nutrient homeostasis in C57BL/6J mice with sustained circulating human IL6 (hIL6) secreted predominantly from brain and lung (h IL6tg mice).

Therefore, in the present study we used mice with sustained elevated levels of APC due to endogenous overexpression of hyperactivatable PC (APChigh-mice [ 21]) and investigated the effects of elevated APC levels in the same model of pneumococcal pneumonia [ 19, 20].

The effect of human IL6 on growth and diet-induced obesity in mice To investigate the effect of hIL6 upon nutrient homeostasis, we created mice with sustained circulating hIL6 secreted predominantly from brain and lung (h IL6tg mice) by backcrossing wild-type C57BL/6J mice 12 times with MUP/h IL6 mice expressing human IL6 cDNA under the control of a mouse urinary protein gene promoter.

Thus, a total of 4 of 18 bitransgenic mice with sustained induction became debilitated or died by d80 vs. 0 of 12 control mice.

In contrast to the abortive infection in WT mice, HCV could infect C/OTg mice (n = 67) with sustained viral RNA levels (see Supplementary information, Tables S3 and S4 for mouse allocation and genome copy numbers, respectively) for over 12 months post infection (mpi), in both serum and liver.

Upon ischemia induction, Rras −/− (R-Ras knockout, KO) mice exhibited more robust angiogenesis than wild-type mice, producing highly chaotic neovasculature with sustained EC proliferation in the gastrocnemius (GC) muscle (Supplementary Fig. 11) as expected from the absence of R-Ras to attenuate excessive angiogenesis11.

More recently, electrophysiological studies using green fluorescent protein identified GnRH neurons in mice have shown exquisite sensitivity to kisspeptin with sustained action potential firing [38], [39].

Consistent with sustained opioid release, KOR knock-out mice developed significantly increased tactile allodynia and thermal hyperalgesia in both the early (first week) and late (third week) interval after lesion.

Littermate control mice had a recovery sleep lasting about 10 12 hr, with sustained NREM periods remaining 6 hr into the night.