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Here we report that mice with specific ablation of Jnk1 in hepatocytes exhibit glucose intolerance, insulin resistance, and hepatic steatosis.
The same strategy was used to generate mice with specific expression in astrocytes except that a Connexin30-CreERT2 (donated from Frank W Pfrieger), was crossed with a Ai95 RCL-GCaMP6f) mouse.
A series of studies using mice with specific TIMP gene deletions has illuminated the importance of these molecules in biology and pathology.
The present study was designed to determine the response to noise of the auditory system of a genetically well-defined laboratory mouse in preparation for examining the effect of noise on mice with specific genetic mutations.
In order to gain further insight into the ILK-αNAC signaling cascade, we inactivated ILK using RNA knockdown in osteoblastic cells and engineered mice with specific ablation of ILK in osteoblasts.
Finally, I demonstrate that mice with specific loss of Bmp2 in nephron precursors and their derivatives results in a fraction of disconnected mature nephrons that later results in nephron atrophy and compromised renal function at juvenile stage compared to control mice.
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It is possible that this is characteristic of mice with particular and specific motor disabilities.
There are many "heart failure model mice" with cardiomyocyte specific gene modification35.
To determine how different genes affect disease vulnerability or progression, many researchers use "knockout" mice, with one specific gene deleted or inactivated.
Sir Martin performed pioneering research into stem cells, and used them to create mice with a specific genetic disorder.
Genetically engineered mice with a specific deletion of targeted genes provide a novel and useful tool to study the endogenous mechanisms underlying aberrant behaviour.
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