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In H69 tumour-bearing mice with small tumours, two animals showed stable disease and in eight animals, a partial response was found after treatment.
Pretargeted immuno-PET was compared to 18F-FDG-PET in a preclinical orthotopic model in mice with small, intraperitoneally growing CEA-expressing colonic tumor lesions.
Whether this method is also useful for analyzing more subtle effects of neuroprotective treatment (partial protection) remains to be established, by studying mice with small dopaminergic lesions.
For in vivo studies, mice with small but established tumors were treated for 1 or 3 weeks with a control IgG, a mouse chimeric version of r84 (mcr84), GU81, or sunitinib (Table 1).
This underlines the necessity to perform biodistribution on mice with small tumours only.
Ten mice with small D-12 tumours were included in the first experiment.
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Taken together, μCT analyses of the femur and lumbar spine indicate impaired bone growth in Lrp4ECD mutant mice, with smaller bones of otherwise mostly normal morphology and suggest a concomitant relative increase of bone resorption over bone formation, resulting in a net loss of trabecular bone.
However, EPI-/ SCCs expressed higher TSLP levels and EPI-/ mice bearing papillomas larger than 2mm had higher levels of systemic TSLP than EPI-/ mice with smaller papillomas.
In addition, EPI−/− mice bearing papillomas larger than 2 mm had higher levels of systemic TSLP than EPI−/− mice with smaller papillomas.
However, when mice with smaller tumours (3-6 meanean diameter) are treated with gemcitabine, and compared to vehicle-treated controls, gemcitabine seems to have a beneficial effect on their survival (Fig. 4).
To investigate the corresponding region within the Eae39 locus for disease phenotypes, we produced mice with smaller, overlapping congenic fragments (C2 to C5) and studied the anti-collagen antibody response after immunisation.
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