We noted reduced weight gain between birth and weaning and increased adiposity in adult Magel2-null mice, with reduced food intake and activity levels [15].
Here, we used mice with reduced (50%) or increased STIP1 levels (fivefold) to test for potential ASD-like phenotypes.
Oral dosing of cyclodextrin melarsoprol conjugates cured a stage 2 infection in mice, with reduced host toxicity.
In contrast, for mice with reduced p53 function, the exposure resulted in increased disease severity for up to 60 weeks of exposure, and then protection after 90 weeks.
Similarly, hypothalamic mRNA levels of AgRP, POMC, and NPY are reduced in GHR−/− mice, with reduced inflammation in response to high‐fat diet (HFD) (Baquedano et al., 2014).
Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1.
Natsuga, K., Cipolat, S. & Watt, F. M. Increased bacterial load and expression of antimicrobial peptides in skin of barrier-deficient mice with reduced cancer susceptibility.
Unaffected paired associate memory in the TK+ mice with reduced hippocampal neurogenesis (Fig. 3e) suggests that these forgetting effects are mediated via a neurogenic mechanism.
Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1).
The impaired TCA cycle activity in mice with reduced or null ERRα activity while treated with rapamycin suggests that these mice not only have a decreased capacity to oxidize lipids but the accumulation of citrate is reoriented toward lipid biosynthesis.
We demonstrate here first that KL-2-deficient mice have worse survival and an increased heart/bodyweight ratio post-MI compared to mice with reduced c-Kit receptor expression.
