Sentence examples for mice with precise from inspiring English sources
Although some mice with precise C to T substitution were obtained, indel mutations were also identified quite often in these mice, potentially due to the Cas9 nickase activity (Kim et al., 2017).
To address whether the ZEN method can generate mice with precise genome modifications, we coelectroporated Cas9 mRNA, sgRNA targeting Tet2, and a 126-nt donor oligonucleotide with DNA sequence flanking the target site and a 2-nt mutation converting the naturally occurring EcoRV site (GATATC) in the target sequence to an EcoRI site (GAATTC) and recovered live mice.
Advances in molecular biology have not only allowed detailed studies of spontaneously occurring obese mice with altered melanocortin signaling to be undertaken but also permitted the generation of a plethora of mouse models with precise perturbations at critical steps in the melanocortin system to finesse further the cellular and molecular architecture of relevant pathways.
Including an exciting piece of work published in this volume of Protein and Cell, two groups demonstrated that base editing can be applied to generate mouse models with precise modification very efficiently (Kim et al., 2017).
In conclusion we report here the newest version of the linkage map for the laboratory mouse, with more precise localization of crossover events and more comprehensive coverage of segregating variation than previous maps.
These data demonstrate that mouse strains generated with precise genetic modifications of POMC peptide processing can answer questions about POMC peptide function.
This work brings together electrophysiological data of Purkinje cells selected strictly based on the presence of consistent US-complex spike responses with precise behavioral recordings in an eyeblink conditioning paradigm employing awake behaving mice.
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[Euclidean Metric with Precise Templates (EMP)].
[Metric Learning with Precise Templates (MLP)].
