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Multivariate and univariate analyses of variance indicated that mice with good visual ability performed better than mice with poor visual ability, but the effect sizes were small.
The IP-IP model presents the same limitations as were described when using this protocol in NOD/SCID mice, with poor reproducibility of peripheral parasitemia.
This may be caused by a disrupted growth factor signaling, since we had shown impaired intestinal adaptations during catch-up growth following re-feeding in severe undernourished ApoE knock-out mice, with poor intestinal IGF-1 expression [ 21].
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Ccl2−/− T-bet−/− Rag2−/− (n = 106) and T-bet−/− Rag2−/− (n = 142) mice developed colitis of similar severity over a similar time course, and Ccl2−/− T-bet−/− Rag2−/− mice succumbed with poor body condition, as did T-bet−/− Rag2−/− mice, over the same time frame.
Increased abundance of ΔNp63 in breast cancer cells stimulated metastatic behaviors in culture and in mice and correlated with poor prognosis in patients with mutant p53 positive tumors.
Actually, in humans, unlike in mice, obesity is associated with poor vitamin D status (Bouillon et al., 2014).
Out of 2,742 genes detected in human and 3,552 genes detected in mouse with repeat-poor escapees in their gene bodies (>30% methylation), 794 of them were in common (p value = 8.75 × 10−75).
It is notable that the renal changes are caused by hyperglycaemia instead of direct effects of the EGF-R transgene, and thus the E1-DN mouse model mimics human diabetes with poor glycaemic control.
Recent studies revealed that HIF-1α-induced LOX overexpression promoted the metastasis of breast cancers in a mouse model and was correlated with poor prognosis of ER negative patients [ 48].
In another study on colorectal cancer, Dr. Sun showed that NGAL expression was elevated during the normal mucosa-adenoma-adenocarcinoma sequence, and high NGAL expression promoted tumor growth and liver metastasis in mouse models and was associated with poor survival for patients.
The tumours, which grew on the flanks of the mice, had features of cellular adenocarcinomas, with poor glandular differentiation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com